PROGNOSTIC SIGNIFICANCE OF CHANGES IN HEMATOLOGICAL PARAMETERS AND HEMOSTASIS PARAMETERS IN PATIENTS WITH RHEUMATOID ARTHRITIS AND ANTIPHOSPHOLIPID SYNDROME

Sarycheva Yulia Alexandrovna, Chernysheva Tatiana Viktorovna

Justification. There is no clear information in the literature about antiphospholipid syndrome (APS) in rheumatoid arthritis (RA). The purpose of the study. To study the features of changes in some hematological parameters and the hemostasis parameters in RA patients with and without APS in a comparative aspect. Materials and methods. 105 patients with RA were examined. Results. The platelet count positively correlated in both groups with еrythrocyte sedimentation rate (ESR), C-reactive (CRP), interleukin-18 (IL-18), fibrinogen, endothelin-1, and D-dimer; in RA and APS, with lupus anticoagulant and β2-glycoprotein-1. There was a positive correlation of protrombin index (PTI) with ESR and CRP and a negative correlation between activated partial thromboplastin time (APTT) and CRP. There was a positive correlation of fibrinogen, D-dimer, and endothelin-1 with ESR, CRP, and IL-18. These dependencies were more pronounced in the group of RA patients with APS (p<0,01). Discussion. Significant differences in changes in hematological and hemostatic parameters between groups of RA patients with and without APS were found. Conclusions. APS is an additional aggravating factor that leads to hypercoagulation and thrombotic complications in RA patients.

Keywords:rheumatoid arthritis, antiphospholipid syndrome, hematology, hemostasis, parameters